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DTSTART:20251009T091000
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DTSTAMP:20260429T121206Z
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SUMMARY:Macrophages mediating the Trojan invasion of Candida auris Cross Blood-brain barrier Triggering Neurological Defects in Drosophila
DESCRIPTION:Candida auris, a recently characterized invasive fungal pathogen,  exhibits resistance to a broad spectrum of antifungal medications. Designated by the WHO as one of the pathogenic fungi with a substantial impact on human health, Candida auris has the potential to infect multiple organs, including the brain, through local infiltration and the bloodstream. The specific mechanism by which it breaches the blood-brain barrier remains unclear. Following infection by Candida auris, the host displays a range of neurological and behavioral abnormalities, suggesting its capacity to infiltrate the brain tissue. This study aims to investigate the transgression of Candida auris across the blood-brain barrier into the brain's parenchyma, explore whether this process relies on a Trojan horse mechanism involving peripheral blood macrophages,  clarify the underlying molecular pathways, and provide insights into the mechanisms leading to neurological and behavioral defects as well as brain damage.
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