Two decades of Trichophyton species isolates in Beaumont Hospital. Time to Tri to evaluate the North Dublin fungal dermatophyte landscape

Saoirse Ni Bhaoill (Beaumont Hospital, Dublin, Ireland)

18:10 - 18:15 Monday 13 April Afternoon

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Abstract

Background Trichophyton species, a group of arthrophilic dermtophytes, are the leading cause of superficial fungal skin infections in humans. Keratin is required for growth in host tissue, meaning that trichophyton species infect the skin, hair and nails. These infections are highly prevalent globally, transmitted by person-to-person contact, with risk factors such as close contact, moist environment and pre-existing skin conditions. Their prevalence and species distribution in North Dublin has not previously been studied.    Objectives To undertake a microbiological and epidemiological review of Trichophyton species isolated in Beaumont Hospital focusing on species distribution and clinical significance.    Methods Positive Trichophyton species specimen laboratory results between 2000 and 2020 were extracted from the Beaumont Hospital Information System (BHIS). Data analysis was performed using Microsoft Excel where specimens were categorised according to specimen type and site of sampling.    Results 2193 trichophyton positive specimens from 2112 patients were studied. This included inpatient and outpatient sources. 54.9% of patients were male, 44.7% female and 0.4% unassigned. Positive results were categorized by specimen type (nail clippings: n=1686, skin scrape: n=478, hair: n=9, unspecified: n=14, swabs: n=3, tissue: n=2, skin lesion: n=2). Median age of patients was 45 years. Trichophyton rubrum was the most prevalent pathogen (65%: n=1446) followed by Trichophyton interdigitale (25.95%: n=569). There was no invasive disease.    Conclusions Trichophyton species infections represent a significant clinical challenge due to their prevalence, variety of presentation and potential for recurrence. Understanding the epidemiological distribution of these infections is important from a public health perspective to guide effective prevention strategies.

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