Infectious diseases of livestock cause major financial losses and threaten food security, animal welfare and public health. Vaccination is a highly cost-effective tool to help prevent, control, and eradicate diseases. However, many vaccines currently used to prevent and control livestock diseases are suboptimal. These vaccines are predominantly classical inactivated and live attenuated pathogen products. Whilst these vaccines may provide clinical benefit, by reducing disease severity, they fail to effectively control pathogens. By allowing pathogen replication in the face of immune selective pressure, these vaccines can drive pathogen evolution, enabling the transmission of pathogens that are less effectively controlled. There is therefore a pressing need to develop next-generation vaccines to improve control of livestock pathogens. In this talk, I will introduce examples of different strategies that are being pursued at The Pirbright Institute to help develop improved vaccines against priority viral diseases of ruminants, pigs and poultry; including the application of structural vaccinology to the design of foot-and-mouth disease vaccines; viral vectors to augment cell-mediated immunity to African swine fever and swine influenza; and engineering of live attenuated virus vaccines to augment responses and/or provide multi-pathogen protection.