Background: The vaginal microbiome is an important driver of host gynecological and obstetric health.   We hypothesize that vaginal microbiomes with high relative abundance of bacterial vaginosis (BV) associated taxa (dysbiotic vagitypes) would have distinct host transcriptional profiles from participants with microbiomes dominated by Lactobacillus spp., the organisms associated with “healthy” cervicovaginal microbiomes.  Methods: Vaginal swabs collected from the earliest gestational age of N = 123 pregnant participants of the multiracial Multi-Omic Microbiome Study-Pregnancy Initiative (MOMS-PI) cohort underwent both 16S rRNA gene taxonomic profiling and metatranscriptomic sequencing.  Host differential expression was assessed with DESeq2 and pathway enrichment with STRING.   We validated the directionality and significance of inflammatory gene expression identified with DESeq2 via quantitative polymerase chain reaction (qPCR).  Results: Host transcriptomic profiles from BV-associated vagitypes differed significantly from Lactobacillus spp. vagitypes (adjusted p <0.05); an observation that remained significant even when the data were restricted to just Black participants to eliminate racial confounding of vagitype.  Analysis of significantly differentially expressed genes common to the three notable cervicovaginal pathobionts (Ca. Lachnocurva vaginae, Gardnerella vaginalis, and mixed taxa with no one species reaching >30% relative abundance) demonstrated modulated host genes associated with ubiquitination (YOD1), membrane integrity (EPN1, MAP7D1, TGM3, MPZL3, SPINT1, KIF13B), calcium transport (S100A16, SLCO4A1), reactive oxygen species formation and mitochondrial stability (CSTB), and immune response (S100A9, IER5, CITED2, ILRUN, STK10).  Conclusion: These findings demonstrate that BV-associated taxa correlate with the expression of specific immunomodulatory genes within the local vaginal environment of pregnant women, across racial groups.