Chair(s): Heli Harvala and Maël Bessaud
Welcome

Nic Stonehouse (University of Leeds, UK)

09:00 - 09:15
Keynote Presentation: Seroepidemiology of Enteroviruses: opportunities and challenges

Marga Pons-Salort (Imperial College London, UK)

09:15 - 10:00
Offered paper: Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown in 2021

Kim Benschop (National Institute for Public Health and the Environment, Netherlands)

10:00 - 10:15
Offered paper: Human parechoviruses (HPeV) infections can range from asymptomatic to life threatening, affecting mainly children. Since the absence of a systematic HPeV surveillance, it is difficult to estimate HPeV-burden in Europe.

Laura Bubba (European non-polio enterovirus network, Italy)

10:15 - 10:30
Break

10:30 - 11:00
Offered paper: Environmental surveillance for poliovirus in the UK between 2017-2022. Recurrent isolation of type 1, 2 and 3 vaccine-like polioviruses

Thomas Wilton (National Institute for Biological Standards and Control, UK)

11:00 - 11:15
Offered paper: Rapid, direct sequencing of poliovirus from stool samples for routine AFP surveillance in the Democratic Republic of the Congo

Alex Shaw (Imperial College London, UK)

11:15 - 11:30
Offered paper: Implementing World Health Organization (WHO) Global Action Plan III Containment Safeguards for United States (U.S.) Poliovirus Type 2 Laboratories

Christy Ottendorfer (Centers for Disease Control and Prevention, USA)

11:30 - 11:45
Offered paper: Comparison of evolutionary trajectories of Sabin 2 and nOPV2 polio vaccines

Sarah Carlyle (National Institute for Biological Standards and Control, UK)

11:45 - 12:00
Offered paper: Impact and effectiveness of novel type 2 oral poliovirus vaccine during emergency use listing

Laura Cooper (Imperial College London, UK)

12:00 - 12:15

Lunch, networking and poster viewing

12:15 - 13:45

Monday 06 June, Afternoon

Session 2: Translation and Replication

Chair(s): Toby Tuthill and Bert Semler
Keynote Presentation: Early events during enterovirus replication

Raul Andino (The University of California, San Francisco Medical Center, USA)

13:45 - 14:30
Offered paper: Hsp70 cellular chaperones associate with rhinovirus non-structural proteins in infected cells and are important for the replication of the virus

Aurélie Mousnier (Queen’s University Belfast, UK)

14:30 - 14:45
Offered paper: Human-based models to study genotype dependent infection of Parechovirus A

Inés García Rodríguez (University of Amsterdam, Netherlands)

14:45 - 15:00
Offered paper: Development of a replicon-based strand-specific qPCR assay to investigate FMDV genome replication

Samuel Dobson (University of Leeds, UK)

15:00 - 15:15
Offered paper: Hepatitis A virus re-wires lipid metabolism to promote very-long chain fatty acid (VLCFA) synthesis required for viral RNA replication

Tomoyuki Shiota (Foundation of Biomedical Research and Innovation at Kobe, Japan)

15:15 - 15:30
Break

15:30 - 16:15
Keynote Presentation: Illuminating picornavirus replication and virus-host interactions

Frank van Kuppeveld (Utrecht University, Netherlands)

16:15 - 17:00
Offered paper: The involvement of packaging signals and the poly-C tract in foot-and-mouth disease virus packaging

Chris Neil (The Pirbright Institute, UK)

17:00 - 17:15
Offered paper: The upstream ORFs in picornaviruses: where, how and why?

Valeria Lulla (University of Cambridge, UK)

17:15 - 17:30
Offered paper: Sexual RNA Replication Among Picornaviruses

David Barton (University of Colorado Anschutz Medical Campus, USA)

17:30 - 17:45

Dinner

18:15 - 20:00

Poster session 1

20:00 - 22:00

Tuesday 07 June, Morning

Session 3: Virus entry and structure

Chair(s): Nicola Stonehouse and Pranav Shah
Keynote Presentation: Enterovirus stability and uncoating

Varpu Marjomäki (University of Jyväskylä, Finland)

09:00 - 09:45
Offered paper: Characterization of cross-neutralizing antibodies to poliovirus serotypes 1, 2, and 3

Andrew Charnseky (The Pennsylvania State University, USA)

09:45 - 10:00
Offered paper: Enterovirus genome delivery

Pavel Plevka (Masaryk University, Czech Republic)

10:00 - 10:15
Offered paper: Membrane interactions and uncoating of Aichi virus, a picornavirus that lacks a VP4

James Kelly (The Pirbright Institute, UK)

10:15 - 10:30
Break

10:30 - 11:00
Offered paper: Chemical evolution of Rhinovirus identifies capsid-destabilizing mutations driving low pH-independent genome uncoating

Urs Greber (University of Zurich, Switzerland)

11:00 - 11:15
Offered paper: Characterising the mechanism of enterovirus VP0 maturation cleavage

Natalie Kingston (University of Leeds, UK)

11:15 - 11:30
Offered paper: Mechanistic insights into the anti-enteroviral activity of fluoxetine

Daniel Hurdiss (Utrecht University, Netherlands)

11:30 - 11:45
Offered paper: Using cryo-electron microscopy to understand aphthovirus replication

Pui Yiu Audrey Lai (University of Oxford, UK)

11:45 - 12:00
Late breaking abstracts

12:00 - 12:30

Lunch, networking and poster viewing

12:30 - 14:00

Tuesday 07 June, Afternoon

Session 4: Evolution and diversity

Chair(s): Peter Simmonds and Rosa Pinto
Keynote Presentation: The evolution of HAV from animal reservoirs

Jan Felix Drexler (German Center for Infection Research, Germany)

14:00 - 14:45
Offered paper: Classification and Taxonomy of the Picornaviridae: New Species, Genera and Subfamilies

Nick Knowles (The Pirbright Institute, UK)

14:45 - 15:00
Offered paper: Evolution of Nidoviral Polymerases Via Key Adaptations of the Picornaviral Polymerase Active Site

Olve Peersen (Colorado State University, USA)

15:00 - 15:15
Offered paper: Demonstration of co-infection and trans-encapsidation of viral RNA in vitro using epitope-tagged foot-and-mouth disease viruses.

Kay Childs (The Pirbright Institute, UK)

15:15 - 15:30
Break

15:30 - 16:00
Offered paper: Molecular evolution of immunodeficiency-associated VDPV type 2 case from Argentina

Cristina Lema (Instituto Nacional de Enfermedades Infecciosas, Argentina)

16:00 - 16:15
Offered paper: Insights into picornavirus biology and evolution from deep mutational scanning analyses

Ron Geller (University of València-CSIC, Spain)

16:15 - 16:30
Late breaking abstracts

16:30 - 17:15
Sabin Lecture

Sir Dave Stuart (University of Oxford, UK)

17:15 - 18:15

Dinner

18:30 - 20:00

Poster Session 2

20:00 - 22:00

Wednesday 08 June, Morning

Session 5: Virus-host interactions and immune response

Chair(s): David Barton and Laurent Andreoletti
Keynote Presentation: Foot-and-mouth disease virus carriers: virus persistence in individuals and populations

Bryan Charleston (Pirbright Institute, UK)

09:00 - 09:45
Offered paper: A Global Understanding of How Picornavirus Capsids Escape Antibody Neutralization

Beatriz Álvarez Rodríguez (University of València-CSIC, Spain)

09:45 - 10:00
Offered paper: A Picornavirus that retargets RSK kinases to phosphorylate new substrates

Belén Lizcano Perret (UCLouvain - de Duve Institute, Belgium)

10:00 - 10:15
Offered paper: Structural analysis of the bovine antibody repertoire: contributions of the heavy and light to antigenic recognition

John Clarke (University of Oxford, UK)

10:15 - 10:30
Break

10:30 - 11:00
Offered paper: HAV egress through the apical and basolateral membranes is controlled by the differential use of the hepatocyte traffic network

Rosa Pinto (University of Barcelona, Spain)

11:00 - 11:15
Offered paper: Heparan sulfate binding mediates Enterovirus A71 virulence in immunosuppressed mice

Han Kang Tee (Université de Genève, Switzerland)

11:15 - 11:30
Offered paper: Primate interferon stimulated genes encode potent foot-and-mouth disease virus restriction factors

Soumendu Chakravarti (The Pirbright Institute, UK)

11:30 - 11:45
Offered paper: Structural and functional repurposing of human proteins apparently acquired by picornaviruses in their 2A locus

Eleonore von Castelmur (Linkoping University, Sweden)

11:45 - 12:00

Lunch, networking and poster viewing

12:00 - 13:00

Wednesday 08 June, Afternoon

Session 6: Pathogenesis

Chair(s): Sisko Tauriainen and Graham Belsham
Keynote Presentation: Organoid models for human entero- and parechoviruses

Katja Wolthers (Amsterdam UMC, Netherlands)

13:00 - 13:45
Offered paper: Early emergence and maintenance of major 5' terminally deleted viral RNA forms are associated with the development of acute and persistent CVB3/28 infections in mouse

Domitille Callon (University of Reims, France)

13:45 - 14:00
Offered paper: Pathogenesis linked to proteinase 2A activity during persistent cardiac infection by enteroviruses

Alexis Bouin (University of California Irvine, USA)

14:00 - 14:15
Offered paper: Unravelling the role of immune cells in the viremia of enterovirus-D68

Brigitta Laksono (Erasmus MC, Netherlands)

14:15 - 14:30

Visit to Skipton Castle

14:30 - 18:30

Conference Dinner and Entertainment

20:00 - 23:00

Thursday 09 June, Morning

Session 7: Treatment and prevention

Chair(s): David Rowlands and Kimberly Benschop
Keynote Presentation: Facing the Oral Poliovirus Vaccine Paradox

Cara Burns (Centers for Disease Control and Prevention, USA)

09:45 - 10:30
Offered paper: Initial use of type 2 novel OPV for immunisation campaigns in several countries

Javier Martin (National Institute for Biological Standards and Control, UK)

10:30 - 10:45
Break

10:45 - 11:15
Offered paper: Protease-free production of poliovirus VLPs using Pichia pastoris: Insights into particle formation and potential vaccine candidates

Lee Sherry (University of Leeds, UK)

11:15 - 11:30
Offered paper: Design of stable Enterovirus A71-C4 virus like particles (VLPs) as a potential approach to vaccine development

Agnieszka Martyna (National Institute for Biological Standards and Control, UK)

11:30 - 11:45
Offered paper: Immunogenicity of polio VLPs formulated with adjuvants

Andrew Macadam (National Institute for Biological Standards and Control, UK)

11:45 - 12:00

Lunch

12:00 - 13:15

Thursday 09 June, Afternoon

Arrival reception and BBQ

Chair(s): Heli Harvala and Maël Bessaud

Welcome

Keynote Presentation: Seroepidemiology of Enteroviruses: opportunities and challenges

Offered paper: Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown in 2021

Offered paper: Human parechoviruses (HPeV) infections can range from asymptomatic to life threatening, affecting mainly children. Since the absence of a systematic HPeV surveillance, it is difficult to estimate HPeV-burden in Europe.

Break

Offered paper: Environmental surveillance for poliovirus in the UK between 2017-2022. Recurrent isolation of type 1, 2 and 3 vaccine-like polioviruses

Offered paper: Rapid, direct sequencing of poliovirus from stool samples for routine AFP surveillance in the Democratic Republic of the Congo

Offered paper: Implementing World Health Organization (WHO) Global Action Plan III Containment Safeguards for United States (U.S.) Poliovirus Type 2 Laboratories

Offered paper: Comparison of evolutionary trajectories of Sabin 2 and nOPV2 polio vaccines

Offered paper: Impact and effectiveness of novel type 2 oral poliovirus vaccine during emergency use listing

Lunch, networking and poster viewing

Chair(s): Toby Tuthill and Bert Semler

Keynote Presentation: Early events during enterovirus replication

Offered paper: Hsp70 cellular chaperones associate with rhinovirus non-structural proteins in infected cells and are important for the replication of the virus

Offered paper: Human-based models to study genotype dependent infection of Parechovirus A

Offered paper: Development of a replicon-based strand-specific qPCR assay to investigate FMDV genome replication

Offered paper: Hepatitis A virus re-wires lipid metabolism to promote very-long chain fatty acid (VLCFA) synthesis required for viral RNA replication

Break

Keynote Presentation: Illuminating picornavirus replication and virus-host interactions

Offered paper: The involvement of packaging signals and the poly-C tract in foot-and-mouth disease virus packaging

Offered paper: The upstream ORFs in picornaviruses: where, how and why?

Offered paper: Sexual RNA Replication Among Picornaviruses

Dinner

Poster session 1

Chair(s): Nicola Stonehouse and Pranav Shah

Keynote Presentation: Enterovirus stability and uncoating

Offered paper: Characterization of cross-neutralizing antibodies to poliovirus serotypes 1, 2, and 3

Offered paper: Enterovirus genome delivery

Offered paper: Membrane interactions and uncoating of Aichi virus, a picornavirus that lacks a VP4

Break

Offered paper: Chemical evolution of Rhinovirus identifies capsid-destabilizing mutations driving low pH-independent genome uncoating

Offered paper: Characterising the mechanism of enterovirus VP0 maturation cleavage

Offered paper: Mechanistic insights into the anti-enteroviral activity of fluoxetine

Offered paper: Using cryo-electron microscopy to understand aphthovirus replication

Late breaking abstracts

Lunch, networking and poster viewing

Chair(s): Peter Simmonds and Rosa Pinto

Keynote Presentation: The evolution of HAV from animal reservoirs

Offered paper: Classification and Taxonomy of the Picornaviridae: New Species, Genera and Subfamilies

Offered paper: Evolution of Nidoviral Polymerases Via Key Adaptations of the Picornaviral Polymerase Active Site

Offered paper: Demonstration of co-infection and trans-encapsidation of viral RNA in vitro using epitope-tagged foot-and-mouth disease viruses.

Break

Offered paper: Molecular evolution of immunodeficiency-associated VDPV type 2 case from Argentina

Offered paper: Insights into picornavirus biology and evolution from deep mutational scanning analyses

Late breaking abstracts

Sabin Lecture

Dinner

Poster Session 2

Chair(s): David Barton and Laurent Andreoletti

Keynote Presentation: Foot-and-mouth disease virus carriers: virus persistence in individuals and populations

Offered paper: A Global Understanding of How Picornavirus Capsids Escape Antibody Neutralization

Offered paper: A Picornavirus that retargets RSK kinases to phosphorylate new substrates

Offered paper: Structural analysis of the bovine antibody repertoire: contributions of the heavy and light to antigenic recognition

Break

Offered paper: HAV egress through the apical and basolateral membranes is controlled by the differential use of the hepatocyte traffic network

Offered paper: Heparan sulfate binding mediates Enterovirus A71 virulence in immunosuppressed mice

Offered paper: Primate interferon stimulated genes encode potent foot-and-mouth disease virus restriction factors

Offered paper: Structural and functional repurposing of human proteins apparently acquired by picornaviruses in their 2A locus

Lunch, networking and poster viewing

Chair(s): Sisko Tauriainen and Graham Belsham

Keynote Presentation: Organoid models for human entero- and parechoviruses

Offered paper: Early emergence and maintenance of major 5' terminally deleted viral RNA forms are associated with the development of acute and persistent CVB3/28 infections in mouse

Offered paper: Pathogenesis linked to proteinase 2A activity during persistent cardiac infection by enteroviruses

Offered paper: Unravelling the role of immune cells in the viremia of enterovirus-D68

Visit to Skipton Castle

Conference Dinner and Entertainment

Chair(s): David Rowlands and Kimberly Benschop

Keynote Presentation: Facing the Oral Poliovirus Vaccine Paradox

Offered paper: Initial use of type 2 novel OPV for immunisation campaigns in several countries

Break

Offered paper: Protease-free production of poliovirus VLPs using Pichia pastoris: Insights into particle formation and potential vaccine candidates

Offered paper: Design of stable Enterovirus A71-C4 virus like particles (VLPs) as a potential approach to vaccine development

Offered paper: Immunogenicity of polio VLPs formulated with adjuvants

Lunch

Offered paper: Assembly of D-antigenic poliovirus VLPs in a mammalian cell-free translation system

Offered paper: Polyphenols Epigallocatechin Gallate and Resveratrol, and Polyphenol-Functionalized Nanoparticles Prevent Enterovirus Infection through Clustering and Stabilization of the Viruses

Keynote Presentation: Rhinoviruses in asthma & COPD - importance and treatment options

Meeting summary and close