Overview
Thank you for attending the Candida and Candidiasis meeting. The event has now closed. Attendees can view the on-demand recordings of the scientific programme for a month following the meeting, by accessing the event platform.
With thanks to the organising committee.
Chair
Geraldine Butler (University College Dublin, Ireland)
Co-chair
Richard Bennett (Brown University, USA)
Chair of Programme Committee
Mike Lorenz (University of Texas, USA)
Programme
Session View
Monday 22 March, Afternoon
Fungal and Host Signaling I
-
Factors affecting host–Candida interactions during phagocytic attack
-
Candida albicans cell fate is determined by transcription factor condensates acting as super-enhancer-like elements
-
Cooperative role of MAPK pathways in the interaction of Candida albicans with the host epithelium
-
The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans
-
Quorum sensing plays a key role in controlling beta-glucan exposure in response to environmental pH
-
Candidalysins are a new family of cytolytic fungal peptide toxins
-
Break
Immune Biology
-
Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis
-
The globular C1q Receptor is Required for Candida albicans to Stimulate the Epidermal Growth Factor Receptor in Oral Epithelial Cells
-
Adaptive immunity promotes a mutually beneficial interaction with commensal Candida albicans
-
Type I Interferon Production in Response to Candida albicans
-
rHyr1p vaccination protects neonatal mice from disseminated candidiasis
-
Spatial mapping of immunological epitopes in the Candida cell wall using C-type lectin probes
-
Break
Tuesday 23 March, Afternoon
Cell Biology
-
Candida lusitaniae evolution in chronic infections
-
Eisosomes mediate a novel pathway for regulating PI(4,5)P2 in Candida albicans which prevents abnormal cell wall growth
-
Novel factors in heme-iron acquisition revealed by forward genetic analysis
-
Forces during human fungal pathogen filamentous growth
-
Imaging of cytosolic free calcium dynamics reveals stress-specific response and recovery signatures in the fungal pathogen, Candida albicans
-
Lysosome Fusion Maintains Phagosome Integrity during Fungal Infection
-
Break
Fungal and Host Signaling II
-
Polyphosphate mobilisation in the pathobiology of Candida albicans.
-
DNA damage response and checkpoint activation in Candida glabrata
-
Loss of mitochondrial function in C. glabrata induces cross-resistance against fluconazole and macrophage killing
-
Insights into White-Opaque Switching in Candida albicans using Single-cell Visualization
-
The fitness costs and benefits of trisomy of each Candida albicans chromosome
-
Episomal CRISPR/Cas9-based strategy to simultaneously inactivate the entire ALSgene family in Candida orthopsilosis
-
Break
Wednesday 24 March, Afternoon
Cool Tools
-
Functional analysis of essential Candida albicans genes by inducible gene deletion
-
Generation and characterisation of a large library of CRISPR-Cas9 edited strains reveal new key players in Candida parapsilosis biology
-
Novel microfluidic and optogenetic tools for studying dispersion of Candida albicans
-
A PCR assay accurately and rapidly identifies Candida species causing monomicrobial and polymicrobial invasive candidiasis (IC)
-
Cell-penetrating peptides for translocation of molecular cargo into Candida cells
-
Identification of essential genes and fluconazole resistance genes in Candida glabrata by profiling of Hermes transposon insertions
Molecular Pathogenesis
-
The transcription factor Stp2 coordinates metabolic responses and morphogenesis in Candida albicans
-
The landscape of lysine acetylation in Candida albicans
-
High confidence Sir3 binding profiles at Candida glabrata subtelomeric regions
-
Mitochondrial defects result in decreased susceptibility to echinocandins via the transcriptional regulator Pdr1 in Candida glabrata
-
Cross talk between regulation of ergosterol biosynthesis and the Pdr1 transcription factor in Candida glabrata
-
The first multi-omic interaction network in the human pathogen Candida glabrata provides novel insights into the virulence regulator, Hsp90.
-
Break
Thursday 25 March, Afternoon
Drugs and Diagnostics
-
Drug repurposing 2.0: optimising the antifungal activity of FDA-approved drug scaffolds
-
A molecular cost–benefit analysis of antimicrobial resistance in Candida glabrata
-
Unveiling azole resistance mechanisms in Candida glabrata clinical isolates encoding wild-type or gain-of-function CgPdr1 alleles
-
The bacterial glycoside hydrolase PslG inhibits Candida albicans biofilm formation in vitro and in vivo
-
Origin of Candida albicans and related species by hybridization
-
Natural killers: dietary polyphenols as novel antifungal agents
Infection Models
-
Sucrose attenuates mucosal Candida albicans virulence by altering oral bacterial community composition
-
Screening of C. albicans transcription factor (TF) libraries identifies regulators of alkaline and weak acid responses as virulence determinants during intra-abdominal candidiasis (IAC)
-
Candida auris forms robust biofilms in skin niche conditions and on porcine skin
-
Uncovering Candida albicans factors that modulate the host phagocyte response
-
Two catheterised skin models to study C. auris biofilm
-
Evaluation of the pathogenic potential of the emerging fungal pathogen Candida auris using clinically relevant animal models
Metabolism
-
β(1,3)-glucan unmasking attenuates the virulence of Candida albicans in a host immune system-dependent manner
-
Amino acid permeases are required for pH manipulation and virulence in Candida albicans
-
Metabolic reprogramming in the opportunistic yeast Candida albicans in response to hypoxia
-
The interplay of metabolism, chromatin and virulence-related biology of Candida albicans
-
Infection-induced reprogramming of carbohydrate metabolism in oral epithelial cells regulates immune responses to Candida albicans
-
Candida albicans phosphate transport, facilitating nucleotide sugar biosynthesis, contributes to cell wall stability
-
Break
Friday 26 March, Afternoon
Drug Discovery and Resistance
-
Antifungal, turbinmicin, targets vesicle and biofilm matrix production
-
Antibody theranostics for fungal infections
-
Identifying and Characterizing Novel Antifungals
-
Inhibitors of filamentation and biofilm formation as new anti-virulence agents against Candida albicans infections
-
In vitro evolution reveals mutations in Candida auris ERG6 as novel a genetic determinant of clinical amphotericin B resistance
-
Azole Uptake in Candida auris is Strongly Correlated with Drug Resistance
-
Break
Life in the Host
-
The Role of MDSCs in Trained Immunity to Systemic Candidiasis and Sepsis
-
Recoding of DNA binding events during gut commensalism reveals the action of a repurposed Candida albicans regulatory network
-
Profiling dynamic mRNA translation regulation in Candida albicans and its host during infection
-
Immunosurveillance of fungal commensalism in mucosal barrier tissues
-
Control of ß-glucan exposure by the endo-1,3-glucanse Eng1 in Candida albicans
-
The regulatory proteins Rtg1/3 govern sphingolipid homeostasis in Candida albicans
-
Break
Saturday 27 March, Afternoon
Genome dynamics, variation and evolution
-
Host immunity impacts Candida albicans genome stability
-
Development of quantitative trait loci (QTL) mapping in Candida albicans via parasex
-
Chromatin-mediated regulation of stress-induced genome instability in the human fungal pathogen Candida albicans
-
The study of loss-of-heterozygosity within the natural population of Candida albicans
-
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs
-
Identification of genome-wide alternative splicing events in sequential, isogenic clinical isolates of Candida albicans reveals a mechanism important for drug resistance and tolerance to cellular stress
-
Break
The Microbiome
-
The colon microcosm: a novel in vitro model to study Candida albicans colonisation of the human colon
-
The involvement of the Candida glabrata trehalase enzymes in stress resistance and gut colonization
-
Effects of Candida species gastrointestinal colonisation on Clostridioides difficile infection
-
Metabolic cross-talk between fungi and bacteria increases bacterial virulence
-
Candida albicans augments Staphylococcus aureus alpha-toxin production via extracellular alkalinisation
-
The dynamics of the mycobiome during hematopoietic stem cell transplantation
Lecture View
Monday 22 March, Afternoon
-
Factors affecting host–Candida interactions during phagocytic attack
-
Candida albicans cell fate is determined by transcription factor condensates acting as super-enhancer-like elements
-
Cooperative role of MAPK pathways in the interaction of Candida albicans with the host epithelium
-
The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans
-
Quorum sensing plays a key role in controlling beta-glucan exposure in response to environmental pH
-
Candidalysins are a new family of cytolytic fungal peptide toxins
-
Break
-
Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis
-
The globular C1q Receptor is Required for Candida albicans to Stimulate the Epidermal Growth Factor Receptor in Oral Epithelial Cells
-
Adaptive immunity promotes a mutually beneficial interaction with commensal Candida albicans
-
Type I Interferon Production in Response to Candida albicans
-
rHyr1p vaccination protects neonatal mice from disseminated candidiasis
-
Spatial mapping of immunological epitopes in the Candida cell wall using C-type lectin probes
-
Break
-
Session
Tuesday 23 March, Afternoon
-
Candida lusitaniae evolution in chronic infections
-
Eisosomes mediate a novel pathway for regulating PI(4,5)P2 in Candida albicans which prevents abnormal cell wall growth
-
Novel factors in heme-iron acquisition revealed by forward genetic analysis
-
Forces during human fungal pathogen filamentous growth
-
Imaging of cytosolic free calcium dynamics reveals stress-specific response and recovery signatures in the fungal pathogen, Candida albicans
-
Lysosome Fusion Maintains Phagosome Integrity during Fungal Infection
-
Break
-
Polyphosphate mobilisation in the pathobiology of Candida albicans.
-
DNA damage response and checkpoint activation in Candida glabrata
-
Loss of mitochondrial function in C. glabrata induces cross-resistance against fluconazole and macrophage killing
-
Insights into White-Opaque Switching in Candida albicans using Single-cell Visualization
-
The fitness costs and benefits of trisomy of each Candida albicans chromosome
-
Episomal CRISPR/Cas9-based strategy to simultaneously inactivate the entire ALSgene family in Candida orthopsilosis
-
Break
-
Poster Session A
Wednesday 24 March, Afternoon
-
Why outcomes of patients with invasive candidiasis have not improved despite potent antifungal agents and rapid, culture-independent diagnostics
-
Functional analysis of essential Candida albicans genes by inducible gene deletion
-
The transcription factor Stp2 coordinates metabolic responses and morphogenesis in Candida albicans
-
Generation and characterisation of a large library of CRISPR-Cas9 edited strains reveal new key players in Candida parapsilosis biology
-
The landscape of lysine acetylation in Candida albicans
-
Novel microfluidic and optogenetic tools for studying dispersion of Candida albicans
-
High confidence Sir3 binding profiles at Candida glabrata subtelomeric regions
-
Current clinical challenges in Candida and candidiasis – understanding epidemiology and resistance
-
A PCR assay accurately and rapidly identifies Candida species causing monomicrobial and polymicrobial invasive candidiasis (IC)
-
Mitochondrial defects result in decreased susceptibility to echinocandins via the transcriptional regulator Pdr1 in Candida glabrata
-
Cell-penetrating peptides for translocation of molecular cargo into Candida cells
-
Cross talk between regulation of ergosterol biosynthesis and the Pdr1 transcription factor in Candida glabrata
-
Identification of essential genes and fluconazole resistance genes in Candida glabrata by profiling of Hermes transposon insertions
-
The first multi-omic interaction network in the human pathogen Candida glabrata provides novel insights into the virulence regulator, Hsp90.
-
Break
-
Poster Session B
-
Break
-
Candida auris – a public health perspective on the unique challenges of this emergent pathogen
-
Candida auris - a translational biology approach to study epidemiologic risk factors of skin colonization
-
Antifungal resistance in the emerging fungal pathogen Candida auris
-
Discussion
Thursday 25 March, Afternoon
-
Drug repurposing 2.0: optimising the antifungal activity of FDA-approved drug scaffolds
-
Sucrose attenuates mucosal Candida albicans virulence by altering oral bacterial community composition
-
β(1,3)-glucan unmasking attenuates the virulence of Candida albicans in a host immune system-dependent manner
-
A molecular cost–benefit analysis of antimicrobial resistance in Candida glabrata
-
Screening of C. albicans transcription factor (TF) libraries identifies regulators of alkaline and weak acid responses as virulence determinants during intra-abdominal candidiasis (IAC)
-
Amino acid permeases are required for pH manipulation and virulence in Candida albicans
-
Unveiling azole resistance mechanisms in Candida glabrata clinical isolates encoding wild-type or gain-of-function CgPdr1 alleles
-
Candida auris forms robust biofilms in skin niche conditions and on porcine skin
-
Metabolic reprogramming in the opportunistic yeast Candida albicans in response to hypoxia
-
The bacterial glycoside hydrolase PslG inhibits Candida albicans biofilm formation in vitro and in vivo
-
Uncovering Candida albicans factors that modulate the host phagocyte response
-
The interplay of metabolism, chromatin and virulence-related biology of Candida albicans
-
Origin of Candida albicans and related species by hybridization
-
Two catheterised skin models to study C. auris biofilm
-
Infection-induced reprogramming of carbohydrate metabolism in oral epithelial cells regulates immune responses to Candida albicans
-
Natural killers: dietary polyphenols as novel antifungal agents
-
Evaluation of the pathogenic potential of the emerging fungal pathogen Candida auris using clinically relevant animal models
-
Candida albicans phosphate transport, facilitating nucleotide sugar biosynthesis, contributes to cell wall stability
-
Break
-
Poster Session C
-
Break
-
Large-scale Data Resources for the Candida Community: from Genomics to Epidemiology
-
Candida Genome Database - online resource for Candida research community
Friday 26 March, Afternoon
-
Antifungal, turbinmicin, targets vesicle and biofilm matrix production
-
Antibody theranostics for fungal infections
-
Identifying and Characterizing Novel Antifungals
-
Inhibitors of filamentation and biofilm formation as new anti-virulence agents against Candida albicans infections
-
In vitro evolution reveals mutations in Candida auris ERG6 as novel a genetic determinant of clinical amphotericin B resistance
-
Azole Uptake in Candida auris is Strongly Correlated with Drug Resistance
-
Break
-
The Role of MDSCs in Trained Immunity to Systemic Candidiasis and Sepsis
-
Recoding of DNA binding events during gut commensalism reveals the action of a repurposed Candida albicans regulatory network
-
Profiling dynamic mRNA translation regulation in Candida albicans and its host during infection
-
Immunosurveillance of fungal commensalism in mucosal barrier tissues
-
Control of ß-glucan exposure by the endo-1,3-glucanse Eng1 in Candida albicans
-
The regulatory proteins Rtg1/3 govern sphingolipid homeostasis in Candida albicans
-
Break
-
Beyond Neutropenia: Invasive candidiasis causes a wide spectrum of diseases in a variety of hosts
-
Fever in the ICU
-
A case of persistent C. glabrata fungemia
-
Discussion
Saturday 27 March, Afternoon
-
Host immunity impacts Candida albicans genome stability
-
Development of quantitative trait loci (QTL) mapping in Candida albicans via parasex
-
Chromatin-mediated regulation of stress-induced genome instability in the human fungal pathogen Candida albicans
-
The study of loss-of-heterozygosity within the natural population of Candida albicans
-
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs
-
Identification of genome-wide alternative splicing events in sequential, isogenic clinical isolates of Candida albicans reveals a mechanism important for drug resistance and tolerance to cellular stress
-
Break
-
The colon microcosm: a novel in vitro model to study Candida albicans colonisation of the human colon
-
The involvement of the Candida glabrata trehalase enzymes in stress resistance and gut colonization
-
Effects of Candida species gastrointestinal colonisation on Clostridioides difficile infection
-
Metabolic cross-talk between fungi and bacteria increases bacterial virulence
-
Candida albicans augments Staphylococcus aureus alpha-toxin production via extracellular alkalinisation
-
The dynamics of the mycobiome during hematopoietic stem cell transplantation
-
Closing Comments and Poster Awards
Abstracts & posters
Poster Abstract Book
The Microbiology Society is pleased to present a book of abstracts from our presented posters at the Candida and Candidiasis meeting.
Poster Abstract Book
Best Poster Awards
Sponsored by Cidara Therapeutics
All poster presenters will be considered for a ‘Best Poster Prize’ sponsored by Cidara Therapeutics.
A total of five awards and a cash prize will be awarded to the five most highly rated posters.
Contact us
For questions relating to oral or poster presentations please email us at [email protected]
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