The Scientific Seminar Series is designed to reach the microbiology community to disseminate knowledge across its professional networks. The events are designed as a regularly repeated series of short (typically 1–2 hour) online meetings.
The Journal of Medical Microbiology (JMM) monthly seminar series is designed to showcase high-quality and timely research from the journal’s key authors. JMM welcomes everything from laboratory research to clinical trials, including bacteriology, virology, mycology, and parasitology. The JMM seminars will reflect this same comprehensive scientific content.
Sign up to attend this series of seminars via the 'Registration' tab. Instructions on how to join the Zoom session will be sent ahead of each seminar.
Please note all times listed in the programme are UK time.
Efforts to improve the effectiveness of existing interventions for antimicrobial resistant (AMR) infections include finding new ways to overcome resistance to licenced antibiotics using adjuvants, or by using antibiotics in new combinations. While antimicrobial chemotherapy targeting the cell wall (e.g. β-lactams) and folate pathway (e.g. trimethoprim-sulfamethoxazole, TMP-SMX) remains a cornerstone of modern healthcare, resistance to these drugs presents an escalating clinical challenge. We recently reported that purine nucleosides are powerful antibiotic adjuvants that can resensitise methicillin resistant Staphylococcus aureus (MRSA) to β-lactams. More recently we have further identified that purine nucleosides act to downregulate thymidine levels in MRSA cells. Building on this novel mechanistic insight, our data show that purines potentiate both TMP-SMX (folate is a co-factor for thymidine biosynthesis) and 5-fluorouracil (5-FU), which also disrupts pyrimidine metabolism. These discoveries reveal that therapeutic potential of TMP-SMX/purines or 5-FU/purines alone and in combination with β-lactams against MRSA and other pathogens responsible for chronic and difficult to treat infection.
Sign up to attend this series of seminars below. You will receive an email with information about each upcoming presentation, including joining instructions, a Zoom link, and any other relevant information, two days before each seminar. A second reminder email will be sent one hour before each seminar. Unfortunately, if you have signed up less than one hour before the seminar, you will not be able to attend until the next seminar in the series.
Please note all times listed in the programme are UK time.
* By completing and submitting this form, you understand and hereby consent that the personal data provided by you in this form will be collected, processed and used by the Microbiology Society to send you any communication relating to the event. You understand and hereby consent that the personal data provided by you in this form will be collected, processed and used by the Microbiology Society for the following additional purposes, but only if you tick the relevant box above. The Microbiology Society is the data controller for the purpose of Data Protection Legislation. The Microbiology Society is a charity registered in England and Wales (Charity Number 264017), a charity registered in Scotland (Charity Number SC039250) and a company limited by guarantee, registered in England (Company Number 1039582).