In this month's Microbe Talk, Charlotte Holtum (Head of Engagement & Storytelling) welcomes guests Dr Alicia Demirjian (UK Health Security Agency and Guy’s and St. Thomas’ NHS Foundation Trust) and Dr Yoann Personne (bioMérieux), to explore an underdiscussed corner of the antimicrobial resistance conversation: its management with sepsis. They discuss what underpins the real-world relationship of AMR and sepsis, improving antibiotic stewardship in hospitals, and addressing these issues sooner rather than later.